HeLa cells were subjected to SDS PAGE followed by western blot with FNab02811(EPHX2 antibody) at dilution of 1:1000
IP result of anti-EPHX2(IP:FNab02811, 4ug; Detection:FNab02811 1:300) with mouse large intestine tissue lysate 3200 ug
Immunohistochemistry of paraffin-embedded human colon cancer using FNab02811(EPHX2 antibody) at dilution of 1:100
Background
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides(alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.